Antibacterial Activity of Triterpenoid from The Leaves of Tahi Ayam (Lantana camara Linn)

Kartika MZ, Suryati Suryati, Mai Efdi


Tahi Ayam (Lantana camara Linn) is known as the herbal plant to cure several diseases and has been used in folk medicine. The result of this study indicates that the isolated compound and the ethyl acetate fraction are components having antibacterial activity. The isolated compound from the ethyl acetate fraction from the leaves of the Lantana camara Linn plant is 9-hydroxy-Lantadene A. The compound includes the triterpenoid compound group, the molecular formula is C35H52O6, and another name is 22-angeloiloxy-9-hydroxy-3-oxo-olean-12-en-28-oat. The antibacterial activity of this compound was determined by looking at the inhibition zone of the test bacteria, namely Staphylococcus aureus as gram-positive and Escherichia coli as gram-negative. The treatment has been using the disc diffusion method and using amoxicillin as a control positive. The result of the antibacterial activity test revealed that both 9-hydroxy-Lantadene A and the ethyl acetate fraction exhibited antibacterial activity. Becouse there are inhibition zones around the discs at concentrations of 10 μg/disk and 5 μg/disk.

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Tiwari, P and Krishanu , S. Preliminary physico – Phytochemical & phyto cognostical evaluation of the leaves of Lantana camara. Journal of Pharmacognosy and Phytochemistry. 12(1) 592-596. 2023

Olowa, L. F.; Nuñeza, O. M. Brine Shrimp Lethality Assay of the Ethanolic Extracts of Three Selected Species of Medicinal Plants from Iligan City, Philippines. International Research Journal of Biological Sciences. 2, 74-77. 2013

Caesar, P.; Kumar, a. J. Studies on Phytochemical Screening of Leaf Fraction of Lantana camara Linn. Journal of Pharmacy Research. 10, 304-307. 2016

Swamy, M. K.; Sinniah, U. R.; Akhtar, M. S. In Vitro Pharmacological Activities and GC-MS Analysis of Different Solvent Extracts of Lantana camara Leaves Collected from Tropical Region of Malaysia. Evidence-Based Complementary and Alternative Medicine. 2015

Bintang, M.; Saputri, D. D.; Fachriyan; Pasaribu, H. Isolation and Characterization of Endophytic Bacteria from Tembelekan (Lantana camara L.) as Antibacterial Compounds Producer. Current Biochemistry. 2, 77 - 89. 2015

Kazmi, I.; Afzal, M.; Ali, B.; Damanhouri, Z. A.; Ahmaol, A.; Anwar, F. Anxiolytic potential of ursolic acid derivative-a stearoyl glucoside isolated from Lantana camara L. (verbanaceae). Asian Pacific Journal of Tropical Medicine. 433-437. 2013

Kazmi, I.; Rahman, M.; Afzal, M.; Gupta, G.; Saleem, S.; Afzal, O.; Shaharyar, M. A.; Nautiyal, U.; Ahmed, S.; Anwar, F. Anti-diabetic potential of ursolic acid stearoyl glucoside: A new triterpenic gycosidic ester from Lantana camara. Fitoterapia. 83, 142–146. 2012

Murugesan, S.; Rajeshkannan, C.; Babu, D. S.; Sumathi, R.; Manivachakam, P. Identification of insecticidal properties in common weed - Lantana camara Linn by Gas Chromatography and Mass Spectrum (GC-MS-MS). Pelagia Research Library. 3, 2754-2759. 2012

Kalita, S.; Kumar, G.; Karthik, L.; Rao, K. V. B. In vitro antioxidant and DNA damage inhibition activity of aqueous extract of Lantana camara L. (Verbenaceae) leaves. Asian Pacific Journal of Tropical Biomedicine. S1675-S1679. 2012

Ediruslan; Manjang, Y.; Suryati; Aziz, H. Structure elucidation of brine shrimp toxic compound from Lantana camara L. leaves. Journal of Chemical and Pharmaceutical Research. 7 250-255. 2015

Apriliana, R; Aldi, Y; Oktavia, S. Effects Of Anti-Inflammatory And Antioxidant Activities Of Lantana (Lantana Camara L). Journal of Pharmaceutical Sciences and Medicine (IJPSM). 6 (8) 144-151. 2021

Suryati; Santoni, A.; MZ, K.; Aziz, H. Antioxidant activity and total phenolic contentof ethyl acetate extract and fractions of Lantana camara L. leaf. Der Pharma Chemica. 8 92-96. 2016

Seepe, H. A; Raphoko, L; Amoo, S. O; Nxumalo, W. Lantadene A and boswellic acid isolated from the leaves of Lantana camara L. have the potential to control phytopathogenic Fusarium species. Heliyon. 8 e12216. 2022

Preethi, A.S; Fajila, K; Sathya, A,; Gayathri K,; Anusuya K. A Comparative Study: In-Vitro Anti-Microbial Activity of Various Parts of Lantana Camara Using Ethanolic Extract, International Journal for Multidisciplinary Research (IJFMR). 5 (2). 2023

Shree, R. L; Geetha, R.; Buvaneswari, K.M.; ShinyJoe, J.R.; Selvakumar, P. A Review on Therapeutic Activity and Medicinal Uses of Lantana Camera Linn. YMER. 21 (12). 2022

Battase, L and Attarde, D. Phytochemical and Medicinal Study Of Lantana Camara Linn. (Verbenaceae) - A Review. Asian J Pharm Clin Res, 14 (9), 20-27. 2021

MZ, K; Suryati; Efdi, M. A Triterpenoid from The Leaves of Tahi Ayam (Lantana camara Linn). Indonesian Journal of Fundamental and Applied Chemistry. 3(1), 18-22. 2018

Naz, R.; Bano. A. Phytochemical screening, antioxidants and antimicrobial potential of Lantana camara in different solvents. Asian Pac J Trop Dis, 3, 480-486. 2013

Mariajancyrani; Chandramohan; Ravikumar. Terpenes and Antimicrobial Activity from Lantana camara Leaves. Research Journal of Recent Sciences, 3, 52-55. 2014

Salem, M. Z.; Ali, H. M.; El-Shanhorey, N. A.; Abdel-Megeed. A. Evaluation of extracts and essential oil from Callistemon viminalis leaves: Antibacterial and antioxidant activities, total phenolic and flavonoid contents. Asian Pacific Journal of Tropical Medicine, 785-791. 2013

Jawetz; Melnick; Adelberg. Medical Microbiology. The McGraw-Hill Companies 26th ed. 2013

Bitrus, A. A.; Peter, O. M, Abbas, M. A.; Goni, M. D. Staphylococcus aureus: A Review of Antimicrobial Resistance Mechanisms. Veterinary Sciences: Research and Reviews. 4 (2) 43. 2018

Pakbin, B.; Brück, W. M.; Rossen, J. W. A.;. Virulence Factors of Enteric Pathogenic Escherichia coli: A Review. Int. J. Mol. Sci. 22, 9922. 2021



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