Study of Antioxidant Activities from Antihypertension Drug Plant of the Indralaya Area
Abstract
Ogan ethnic population in Indralaya, Ogan Ilir District, South Sumatra was known to have used several types of plants, there are Swietenia mahagoni, Averrhoa carambola, Syzygium samarangense, Musa acuminata, Nymphaea rubra, Syzygium polyanthum, and Andrographis paniculata for the treatment of hypertension. But, scientific information has not yet been found secondary metabolites that are responsible for providing these activities. The study began with the extraction of methanol from the seven types of plants using methanol as a solvent. Each thick extract was tested for its activity using the 1,1-diphenyl-1-picryllhydrazyl (DPPH) method. The extract which showed the highest activity (methanol extract) was subsequently carried out in vitro antihypertension test using the Angiotencyn Converting Enzyme (ACE) method. Antioxidant test results showed that the methanol extract from S. samarangense stem bark had the highest antioxidant activity with IC50 was 83.06 μg/mL. Antihypertension test of methanol extract from S. samarangense stem bark obtained IC50 ACE was 61.56 μg/mL. Based on the IC50 value, it shows that S. samarangense stem bark has potential as a source of antioxidant compounds as well as a source of antihypertension compounds.
Keywords: Syzygium samarangense, stem bark, antioxidant, antihypertension
Full Text:
Full Text PDFReferences
Ahmad I, Yanuar A, Mulia K, Mun’im A. “Review of Angiotensin-Converting Enzyme Inhibitory Assay: Rapid Method in Drug Discovery of Herbal Plants”, Phcog Rev, vol. 11, pp. 1-7, 2017.
Arihara K, Nakashima, Mukai T, Ishikawa S, Itoh M. “Peptide Inhibitors for Angiotensin I-Converting Enzyme from Enzymatic Hydrolysates of Porcine Skeletal Muscle Proteins”, Meat Science, vol. 5, no. 7, pp. 319-324, 2001.
Boadu and Asase. “Documentation of Herbal Medicines Used for the Treatment and Management of Human Diseases by Some Communities in Southern Ghana”, Evidance-Based Complementary and Alternative Medicine, vol. 20, no. 17, pp. 1-12, 2017.
Budiari S. “Aktivitas Inhibitor Angiotensin Converting Enzyme (ACE) Ekstrak Daging Ikan Gabus (Chonna striata)” tesis, Intitut Pertanian Bogor, Bogor, 2018.
Dewi AS, Tarman K, Uria AR. “Marine Natural Product: Prospect and Impacts on the Sustainable Development in Indonesia. Proceeding of Indonesia Students Scientific Meeting”, The Netherlands, vol. 1, pp. 54-62, 2008.
Durango NM et al. “Role of the Renin-Angiotensin-Aldosterone System beyond Blood Pressure Regulation: Molecular and Cellular Mechanisms Involved in End-Organ Damage during Arterial Hypertension”, International Journal of Molecular Science, vol. 17, no. 797, pp. 1-17, 2016
Eddouks M, Ajebli M, Hebi M. “Ethnopharmacological Survey of Medicinal Plants Used in Daraa-Tafilalet Region (Province of Errachidia), Morocco”, J Ethnopharmacol, vol. 19. no. 18, pp. 516-530, 2017.
Heinrich M. “Ethnobotany and Natural Products: The Search for New Molecules, New Treatments of Old Diseases or a Better Understanding of Indigenous Culture”, Currents Topics in Medicinal Chemistry, vol. 3, no. 3, pp. 29-42.
Jin Li et al. “Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats”, Scientific Reports, vol. 7, no. 15607, pp. 1-14, 2017.
Julkipli et al. “Introduction of Bioprospecting Opportunities for Indonesian Mangrove Species”. IOP Conf, Earth and Environmental Science, 183, 2018.
Junior AG et al. “Antihypertensive Effects of Isoquercitrin and Extracts from Tropaeolum majus L: Evidence for the Inhibition of Angiotensin Converting Enzyme”, Journal of Ethnopharmacology, vol. 134, no. 1, pp. 363-372, 2011.
Kouchmeshky A, Jameie SB, Amin G, Ziai SA. “Investigation of Angiotensin-Converting Enzyme Inhibitory Effects of Medicinal Plants Used in Traditional Persian Medicine for Treatment of Hypertension: Screening Study”. Thrita Stud J Med, vol. 1, no. 1, pp. 13-23, 2012.
Mahomoodally MF. “Traditional Medicines in Africa: An Appraisal of Ten Potent African Medicinal Plants”, Evidance-Based Complementary and Alternative Medicine, vol. 20, no. 13, pp. 1-14, 2013.
McClatchey WC, Mahady GB, Bennelt BC, Shiels L, Valentina. “Ethnobotany as a Pharmacological Research Tool and Recent Developments in CNS-active Natural Products from Ethnobotanical Sources”, Pharmacol Ther, vol. 123, no. 2, pp. 239-254, 2009.
Molyneux P. “The Use of the Stable Free Radical Diphenylpicrylhydrazyl (DPPH) for Estimating Antioxidant Activity”, Songklanakarin J. Sci. Technol, vol. 26, no. 2, pp. 211-219, 2004.
Muharni, Elfita, Masyita. “Isolasi Senyawa Metabolit Sekunder Dari Ekstrak n-Heksana Batang Tumbuhan Brotowali (Tinosporacrispa L.)”, Molekul, vol. 10, no. 1, pp. 38–44, 2015.
Muthia R, Suganda AG, Sukandar EY. “Angiotensin-I Converting Enzyme (ACE) Inhibitory Activity of Several Indonesian Medicinal Plants”, RJPBCS, vol. 8, no. 15, pp. 192-199, 2017.
Nadar S and Lip GYH. "Hypertension (2nd ed)”, Oxford University Press, Oxford, 2015.
Pan SY et al. “New Prespectives on How to Discover Drugs from Herbal Medicines: CAM’s Outstanding Contribution to Modern Therapeutics”, Evidance-Based Complementary and Alternative Medicine, vol. 20, no. 13, pp. 1-25, 2013.
Parto Y, Setiawan D, Elfita, Suwono I, Gozali K. “Riset Khusus Eksplorasi Pengetahuan Lokal Etnomedisin dan Tumbuhan Obat di Indonesia Berbasis Komunitas (Wilayah Ogan)”, Unsri, Palembang, 2012.
Rodriguez CJ et al. “Systolic Blood Pressure Levels Among Adults With Hypertension and Incident Cardiovascular Events: The Altherosclerosis Risk in Communities Study”, Jama Intern Med, vol. 174, no. 8, pp. 1252-1261, 2014.
Supiandi MI, Mahanal S, Zubaidah S, Julung H, Ege B. “Ethnobotany of Traditional Medicine Plants Used by Dayak Desa Community in Sintang, West Kalimantan, Indonesia”, Biodiversitas, vol. 20, no. 5, pp. 1264-1270, 2019.
Taek MM, Prajogo BEW, Agil M. “Plants Used in Traditional Medicine for Treatment of Malaria by Tetun Ethnic People in West Timor Indonesia”, Asian Pacific Journal of Tropical Medicine, vol. 11, no. 11, pp. 630-637, 2018.
Udem SC, Obidike RI, Onyejekwe. “Preliminary Investigation Into the Acute and Chronic Ingestion of Aqueous Leaf Extract of Swietenia Mahagoni (Maliaceae) in rats”, Comporative Clinical Pathology, vol. 21, no. 5, pp. 813-817, 2012.
Valli M et al. “Tropical Biodiversity: Has It Been a Potential Source of Secondary Metabolites Useful for Medicinal Chemistry”, Quim Nova, vol. 35, no. 11, pp. 2278-22, 2012.
DOI: http://dx.doi.org/10.24845/ijfac.v5.i1.22
Refbacks
- There are currently no refbacks.
Editorial Office:
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya
Jl. Palembang-Prabumulih Km.35 Indralaya Ogan Ilir Sumatera Selatan 30662
IJFAC by Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sriwijaya is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License