Isolation of Flavonoid Compound and Antioxidant Activity of Salix tetrasperma Roxb. Leaves

Ria Januarti, Adlis Santoni, Mai Efdi

Abstract


Salix Tetrasperma Roxb. is a plant that found in Indonesia were used as traditional medicine such as diabetes and wound healing. In this study, a flavonoid compound of the ethyl acetate extract of Salix tetrasperma Roxb. leaves was isolated by chromatography technique and the antioxidant activity was determined by DPPH assay. The isolation led to obtain 5,7-dihydroxy-3'-methoxyflavone based on NMR spectra. The ethyl acetate extract exhibited the highest antioxidant activity with the IC50 is 65.89 µg/mL. This study shows that the Salix tetrasperma Roxb. has good potential as source of antioxidant agent.


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References


N. Paul Anulika, E. Osamiabe Ignatius, E. Sunday Raymond, O.-I. Osasere, and A. Hilda Abiola, “The Chemistry of Natural Product: Plant Secondary Metabolites,” Int. J. Technol. Enhanc. Emerg. Eng. Res., vol. 4, pp. 1-8, 2016.

K. Aleksandra, Szostak-Węgierek Dorota. “Flavonoids-Food sources and Health Benefits”, Rocz Panstw Zakl Hig, vol. 65, no. 2, pp. 79-85, 2014.

M. H. Ibrahim, H. Z. E. Jaafar, E. Karimi, and A. Ghasemzadeh, “Primary, secondary metabolites, photosynthetic capacity and antioxidant activity of the Malaysian Herb Kacip Fatimah (Labisia Pumila Benth) exposed to potassium fertilization under greenhouse conditions.,” Int. J. Mol. Sci., vol. 13, no. 11, pp. 15321–42, Nov. 2012.

G. Agati, E. Azzarello, S. Pollastri, and M. Tattini, “Flavonoids as antioxidants in plants: Location and functional significance,” Plant Sci., vol. 196, pp. 67–76, Nov. 2012.

T. P. T. Cushnie and A. J. Lamb, “Antimicrobial activity of flavonoids.,” Int. J. Antimicrob. Agents, vol. 26, no. 5, pp. 343–56, Nov. 2005.

A. Wasim et al., “Flavone’s Worth in the Development of Anticancer Agents,” Int. J. Drug Dev. Res., vol. 9, no. 2, pp. 26–32, May 2009.

U. Rawat et al., “A New Flavonoid Glycoside from Salix denticulata Aerial Parts,” Molbank, vol. 2009, no. 3, p. M622, Sep. 2009.

P. T. Kekuda, K.S. Vinayaka and P. S. Kumar, “Antimicrobial activity of Salix tetrasperma Roxb. (Salicaceae),” Int. J. Herb. Med., vol. 5, no. 5, pp. 192–195, 2017.

J. H. Virupaksha, R. R. Nadendla, and M. Satishkumar, “Evaluation of Antinociceptive and Antipyretic Activities of Salix Tetrasperma Roxburg,” Int. J. Pharma Bio Sci., vol. 7, no. 3, pp. 89–94, 2016.

R. N. Kishore, T. Mangilal, N. Anjaneyulu, G. Abhinayani, and N. Sravya, “Investigation of Anti-Inflammatory and Invitro Antioxidant Activities of Hydroalcoholic Extract of Bark of Salix Tetrasperma Roxb,” Int. J. Pharm. Drug Anal., vol. 2, no. 5, pp. 506–509, 2014.

C. R. Raj, GK. Dash, M. Sumanta, and S. Parhi, “Studies on the Hypoglycaemic Activity of The Bark of Salix tetrasperma Roxb.,” Int. J. Drug Dev. Res., vol. 2, no. 4, 2009.

M. S. Islam et al., “Antibacterial, Insecticidal and in Vivocytotoxicity Activities of Salix Tetrasperma,” Int. J. Pharm. Sci. Res., vol. 2, no. 8, pp. 2103–2108, 2011.

M. Sumanta, H. Ramana, and C. Rishi Raj, “Studies on Diuretic and Laxative Activity of the Bark of Salix Tetrasperma Roxburgh,” Int. Res. J. Pharm., vol. 1, no. 1, pp. 145–149, 2010.

T. P. Kekuda, K. S. Vinayaka, and H. L. Raghavendra, “Ethnobotanical uses, phytochemistry and biological activities of Salix tetrasperma roxb. (Salicaceae) - A review,” J. Med. Plants Stud., vol. 5, no. 5, pp. 203–208, 2017.

A. El-Shazly, A. El-Sayed, and E. Fikrey, “Bioactive secondary metabolites from Salix tetrasperma Roxb.,” Zeitschrift fur Naturforschung. C, vol. 67, no. 7–8, pp. 353–359, 2012.

X. Li et al., “Isolation and characterization of phenolic compounds from the leaves of Salix matsudana.,” Molecules, vol. 13, no. 8, pp. 1530–7, Aug. 2008.

J. B. Harbome. Phytochemical Methods A guide to Modern Techniques of Plant Analysis. Chapman & Hall, vol. Third edition, 1998

M. Mabry, K.R. Markham, and M.B. Thomas. The Systematic Identification of Flavonoids. Springer. New York”, p. 41, 2013

R. A. Gomes et al., “Phenolic compounds from Sidastrum micranthum (A. St.-Hil.) fryxell and evaluation of acacetin and 7,4’-Di-O-methylisoscutellarein as motulator of bacterial drug resistence,” Quim. Nova, vol. 34, no. 8, pp. 1385–1388, 2011.

I. Fidrianny, I. Rahmiyani, and K. R. Wirasutisna, “Antioxidant capacities from various leaves extracts of four varieties mangoes using DPPH, ABTS assays and correlation with total phenolic, flavonoid, carotenoid | Request PDF,” Int. J. Pharm. Pharm. Sci., vol. 5, no. 4, pp. 189–194, 2013.

C. A. Martínez, O. M. Mosquera, J. Niño, C. A. Martínez, O. M. Mosquera, and J. Niño, “Apigenin glycoside: an antioxidant isolated from Alchornea coelophylla pax & k. Hoffm. (euphorbiaceae) leaf extract,” Univ. Sci., vol. 21, no. 3, p. 245, Oct. 2016.




DOI: http://dx.doi.org/10.24845/ijfac.v4.i2.42

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